Your method in DB-ALM

Experts and researchers working on advanced and alternative approaches are invited to share their methodology with our user community from over 82 countries. The DB-ALM includes non-animal methods from a wide field of applications at all stages of development and acceptance in use for regulatory testing or in biomedical research.

We accept new method summaries and/or protocols or proposals for updates to those already available in our collection, provided that they meet our Content Criteria.

Method Formats

Method descriptions are provided with two levels of detail: method summary descriptions on the applications, scientific principle, status of development and acceptance, and protocols including technical procedures that allow the transfer of a method to another laboratory.

The following formats can be used for:

  • Method Summary Description (OECD compliance)
    The reporting format in MS Word can be downloaded from here: Method Summary
    The Content Criteria Document provides guidance on the compilation.
  • Protocols
    If you want to submit a Protocol to be published as a stand-alone document (without a Method Summary description) please use the following format: Protocol (stand-alone)
    If you want to submit a Protocol associated with your Method Summary please use the short version of the protocol format: Protocol (short)
    The Content Criteria Document provides guidance on the compilation.


Minimum acceptance criteria for including a non-animal method into DB-ALM

  1. The proposed method must refer to scientific models/methods/approaches relevant in biomedical and/or toxicological studies and not entailing the use of whole living animals, e.g.: methods for routine toxicity testing of chemicals; safety, efficacy or biocompatibility testing of medicinal products as well as mechanistic studies for research or regulatory purposes.
  2. The method will be accepted if backed up by publications in a peer-reviewed scientific journal(s) and/or developed/optimised during (inter)national projects (including EU Framework Programs) or validation studies.
  3. The method can be at any stage of development, validation and/or acceptance.
  4. Precise and comprehensive information has to be provided in compliance with the requirements following the respective "Content Criteria Documents".


Please send all compiled documents and attachments to
Should you have any other questions or comments, do not hesitate to contact us.

We are currently working on an interactive online application to create, edit and track the publication progress of the method descriptions.

Revision process

The data sheets for methods (Summaries or Protocols) and related data sectors are prepared by JRC external scientists or EURL ECVAM's experts. After submission of a method description to the DB-ALM, examination is performed, such as for consistency and completeness being in line with the database requirements for data content (detailed in the Content Criteria Documents), structure and ensuring the use of the controlled vocabularies. Furthermore, quality control of the finalised data sheets is carried out by the DB-ALM staff before public access is allowed which is done however only after approval of the method contact. Consequently, a method description could pass through a few draft stages before publication.