Data Coverage

Fields of Application

The information available in the DB-ALM originates from (inter)national research projects, individual submissions from scientists, validation studies or bibliographic reviews, which have been performed on selected priority topics (fields of application). These systematic data collection activities in the form of thematic reviews have been carried out so far on 5 topics: Effects on reproduction, Eye Irritation, Hepatotoxicity/Metabolism-mediated toxicity, Neurotoxicity and Percutaneous absorption, for which also selected validation studies are described.

In total, detailed DB-ALM method descriptions, presented as comprehensive method summaries or individual protocols, are available for 26 different topic areas which comprise main topics and subtopics (not shown in the table below). Whenever available, the methods validated by the EURL ECVAM are included.

Main TopicNumber of Data Sheets
Basal Cytotoxicity28
Biocompatibility & Safety of Medical Devices3
Cancer Research9
Culture Methods19
Environmental Toxicity6
Local Toxicity127
Pyrogenicity testing2
Sensitisation and Allergy7
Target Organ/System Toxicity173

NOTE: The topics covered are listed in alphabetical order. Some originated during the feasibility study when the service was initially set up.

Biological Endpoints

The DB-ALM method descriptions cover approximately 250 biological endpoints referring to biological processes, responses or effects that can be assessed at various levels of biological and molecular organisation. They include mechanistic, basal cytotoxicity as well as tissue-type, organ and organism specific parameters.

Biological Endpoint ClustersNumber
Molecular interactions:
physicochemical, biochemical and biokinetic parameters
Cellular level:
proliferation, damage, metabolic and morphological effects
Tissue- and organ-specific functions and effects143
Model organism responses27

Data Sectors

The information content of the DB-ALM is divided across different data sectors. It covers not only the topics and method descriptions, but also a selection of relevant projects and studies, compounds, experiments with their test results, bibliographic references and contact details of persons and institutions active in the field of alternative methods. Further information is provided in The DB-ALM Project section.

Disclaimer: The numbers given refer to the information content currently available online and are subject to frequent variations, since the public version of DB-ALM is updated monthly on average

Last page update: September 2017