The information available in the DB-ALM originates from (inter)national research projects, individual submissions from scientists, validation studies or bibliographic reviews, which have been performed on selected priority topics (fields of application). These systematic data collection activities in the form of thematic reviews have been carried out so far on 5 topics: Effects on reproduction, Eye Irritation, Hepatotoxicity/Metabolism-mediated toxicity, Neurotoxicity and Percutaneous absorption, for which also selected validation studies are described.
In total, detailed DB-ALM method descriptions, presented as comprehensive method summaries or individual protocols, are available for 26 different topic areas which comprise main topics and subtopics (not shown in the table below). Whenever available, the methods validated by the EURL ECVAM are included.
|Main Topic||Number of Data Sheets|
|Biocompatibility & Safety of Medical Devices||3|
|Sensitisation and Allergy||7|
|Target Organ/System Toxicity||173|
NOTE: The topics covered are listed in alphabetical order. Some originated during the feasibility study when the service was initially set up.
The DB-ALM method descriptions cover approximately 250 biological endpoints referring to biological processes, responses or effects that can be assessed at various levels of biological and molecular organisation. They include mechanistic, basal cytotoxicity as well as tissue-type, organ and organism specific parameters.
|Biological Endpoint Clusters||Number|
physicochemical, biochemical and biokinetic parameters
proliferation, damage, metabolic and morphological effects
|Tissue- and organ-specific functions and effects||143|
|Model organism responses||27|
The information content of the DB-ALM is divided across different data sectors. It covers not only the topics and method descriptions, but also a selection of relevant projects and studies, compounds, experiments with their test results, bibliographic references and contact details of persons and institutions active in the field of alternative methods. Further information is provided in The DB-ALM Project section.
Disclaimer: The numbers given refer to the information content currently available online and are subject to frequent variations, since the public version of DB-ALM is updated monthly on average