Suggested Information Resources

Databases and Information Services

Animal Welfare Information Centre (AWIC) The Animal Welfare Information Center (AWIC), located in USDA's National Agricultural Library, is mandated by the Animal Welfare Act (AWA) to provide information for improved animal care and use in research, testing, teaching, and exhibition.

ALTBIB - Bibliography on Alternatives to Animal Testing ALTBIB, Bibliography on Alternatives to Use of Live Vertebrates in Biomedical Research and Testing located at the United States National Library of Medicine (NLM).

AltTox - Non-animal methods for toxicity testing AltTox is a website dedicated to advancing non-animal methods of toxicity testing through information exchange. AltTox offers an informational section on toxicity testing, a set of forums for announcements and discussions, and a series of 'Way Forward' essays written by experts in the field.

Altweb - Alternatives to Animal Testing Altweb, the Alternatives to Animal Testing Web Site, was created to serve as a gateway to alternatives news, information, and resources on the Internet and beyond.

The Humane Endpoints website The 3Rs-Centre Utrecht Life Sciences (ULS) has launched in September 2015 a completely renewed version of the Human Endpoints website which gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species.

The Interspecies Database The 3Rs-Centre Utrecht Life Sciences (ULS) has launched in September 2015 a completely renewed version of the Interspecies Database which provides insight into physiological, anatomical and biochemical parameters of different animal species and humans. Users of the database have reported a reduction in animal use, on average 20% on a yearly basis. The website has been initiated by the Dutch Institute for Public Health and the Environment, which is responsible for the database content.

UCDavis Center for Animal Alternatives Information The UCDavis Center for Animal Alternatives places special emphasis on disseminating up-to-date information concerning animal alternatives through every level of public and private education. It also seeks to provide investigators who use animals with information on the most current methods for improving all aspects of animal care during their work.

ZEBET database on alternatives to animal experiments on the Internet (AnimAlt-ZEBET) One of the tasks of ZEBET is to provide scientists from industry, academia and regulatory agencies with information on alternative methods. For this purpose the ZEBET database on alternative methods to animal experiments 'AnimAlt-ZEBET' was developed. Since February 2000 AnimAlt-ZEBET database has been accessible without license fees on the Internet in German and English through the German Institute for Medical Documentation and Information (DIMDI).

Organisations & Associations

3Rs-Centre Utrecht Life Sciences (3Rs-ULS) The 3Rs-Centre ULS is the 3Rs-Centre of the Utrecht Life Sciences (ULS), a collaboration of local life sciences institutes in the Utrecht area, among which the Utrecht University and the University Medical Center Utrecht. The mission of the 3Rs-Centre ULS is to stimulate the development, acceptation and implementation of 3Rs-methods (Replacement, Reduction and Refinement of animal experiments), by advising and giving information to researchers. The Interspecies Database and the Humane Endpoints website are part of the 3Rs-Database program of the 3Rs-Centre ULS.

Animal Welfare Academy (Akademie fur Tierschutz) The Animal Welfare Academy (Akademie für Tierschutz) is the scientific affilation to the German Animal Welfare Federation (Deutscher Tierschutzbund). One focus of its political and scientific work is in the replacement of animal experiments. Among others, the Academy runs its own cell culture laboratory for this purpose.

Center for Alternatives to Animal Testing (CAAT) The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is an academic, science-based center affiliated with the Johns Hopkins University Bloomberg School of Public Health of the USA. The center has worked with scientists since 1981 to find new methods to replace the use of laboratory animals in experiments, reduce the number of animals tested, and refine necessary tests to eliminate pain and distress. CAAT-EU, housed at the University of Konstanz, coordinates transatlantic activities to promote education in humane science. Working together, CAAT and CAAT-EU aims for scientific synergy involving experts from both sides of Atlantic to promote the implementation of human-relevant alternative approaches, the advancement of research in this field, and the dissemination of the 3Rs.

European Parliament Intergroup on the Welfare and Conservation of Animals The European Parliament All-party Intergroup for the Welfare and Conservation of Animals is a resource for Members of the European Parliament (MEPs) and a place where citizens can monitor MEPs' actions in the field of animal welfare.

European Partnership for Alternative Approaches to Animal Testing (EPAA) The European Partnership for Alternative Approaches to Animal Testing (EPAA) is an unprecedented voluntary collaboration between the European Commission, European trade associations, and companies from seven industry sectors. One of the objectives of the EPAA is to facilitate dissemination of knowledge and information, bringing it to those who need it, in the right format and with sufficient detail.

The EPAA Platform Communication & Dissemination Thematic Review Project

The EPAA has sponsored a project that uses the dissemination platform of the DB-ALM to achieve a systematic review and update of alternative methods in the area of reproductive toxicity testing covering all 3Rs (it doesn't yet cover the topics of developmental neurotoxicity and testing for endocrine disruption that should be subject to a subsequent review).
The thematic review of 3Rs opportunities in the field of reproductive toxicity describes the state of the art of 3Rs approaches at any stage of development (research, validation or regulatory acceptance) relevant for the implementation of the Cosmetic Directive and of REACH. The review provides ready-to-use information in peer-reviewed data sheets with predetermined criteria for data content as developed for ECVAM's DB-ALM that ensures the quality of the information provided.

The EPAA-funded activities included the performance of two surveys with the aim to review the use of alternative methods for Reproductive Toxicity testing in industry. The first survey focused on replacement methods (in vitro/in silico), whereas the second survey covered reduction and refinement (in vivo) methods. The outcome of the project can be accessed via the following link.

European Society of Toxicology in Vitro (ESTIV) ESTIV is a society that aims to promote in vitro toxicology, both scientifically and educationally, in all countries of Europe. This web site will give information on the activities of ESTIV in the field of in vitro toxicology and of alternatives to animal experimentation.

Fund for the Replacement of Animals in Medical Experiments (FRAME) FRAME is a scientific charity, which seeks the total elimination of laboratory animal use, through the development, validation, acceptance and application of scientifically-valid and reasonably-available replacement alternative methods. In addition, FRAME encourages the widest possible adoption of the Three Rs (reduction, refinement and replacement) concept.

Interagency Coordinating Committee on Validation of Alternative Methods (ICCVAM) The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) was established by the ICCVAM Authorization Act of 2000 (Public Law 106-545) as a permanent committee with members from 15 federal agencies. ICCVAM and the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) conduct interagency technical reviews of new, revised, and alternative test methods, and coordinate interagency test method validation, acceptance, and national and international harmonization issues.

In Vitro Testing Industrial Platform (IVTIP) IVTIP is an informal forum of European companies with an active interest in in vitro testing to be used in regulatory/safety testing or to be used in the compound discovery and development process supporting the application, where possible, the principle of the 3Rs: replacing, reducing and refining animal testing. The members represent companies in the chemical, cosmetics and pharmaceutical sector.

National Knowledge Centre on Alternatives (NKCA) The National Knowledge Centre on Alternatives (NKCA) was established in 2010 to promote the application of the 3R alternatives to animal experimentation in the Netherlands. The NKCA was the result of a cooperation between the University of Utrecht and the National Institute for Public Health and the Environment (RIVM). The NKCA was dissolved in December 2014 as a consequence of the implementation of the EU directive in national legislation.

UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) The National Centre for the Replacement, Refinement and Reduction of Animals in Research provides a UK focus for the promotion, development and implementation of the 3Rs in animal research and testing.

ZEBET ZEBET, the German National Centre for Documentation and Evaluation of Alternatives to Animal Experiments, was established in the BfR (Federal Institute for Risk Assessment) in 1989. It is ZEBET's mission to replace particularly regulatory animal tests by alternative test methods, to reduce the number of test animals and to reduce pain and suffering of experimental animals.

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