Press Room & Citations

Year 2016

25 Years! Happy Birthday to EURL ECVAM (December 2016)
Happy 25 years of the EU Reference Laboratory for Alternatives to Animal Testing. DB-ALM also on Twitter.

DB-ALM Newsletter (November 2016)
In addition to the release online of the second version of the revised DB-ALM in October 2016, the information content has been updated with 26 new method descriptions of advanced and alternative methods at all stages of development and acceptance in the areas of Stem cell cultures, Effects on Endocrine Systems, Eye Irritation, Hepatotoxicity, Mutagenicity and Systemic Toxicity.

Release of the complete version of the revised DB-ALM (October 2016)
The EURL ECVAM has released the full version of the entirely revised DB-ALM that was launched in 2014. In addition to the Methods and Topic Summaries data sectors, full access is provided to the data sectors of Project & Studies, Compounds & Test Results, People & Institutions active in the field of Alternative Methods and to Bibliographic References and all related information.

The JRC has just released the biannual DB-ALM progress report 2014 - 2016
The report outlines the progress made during January 2014-June 2016 regarding information content enhancements, system evolution and increasing outreach. Over 300 method descriptions (Summaries and Protocols) are now provided online linked to 82 method evaluations with 3070 test compounds and 9128 results, including experts’ contacts, all originating from National and EU-funded research projects, scientific literature reviews or validation studies towards international acceptance.

Usage of the DB-ALM (August 2016)
DB-ALM could witness a steadily increasing user interest, evidenced in nearly 5000 individual registrations from 82 countries since 2006. Even though data requests could be performed without registration as well as access to a subset of additional information is provided, the service still can refer to a solid number of new users with 499 new registrations in 2015, being the fourth highest during 9 years of public access. The service is referenced in scientific publications, and international institutions active in the Animal Alternatives field refer to it, as well as in OECD formal documents; but is also sourced by the European Chemicals Agency. The OECD recommends DB-ALM as a dissemination platform for compliance with its new Guidance for describing non-guideline in vitro test methods (GD 211). More

ECHA Information toolkit (first accessed in 2010)
ECHA (European Chemicals Agency) suggests the use of ECVAM DB-ALM as a useful information source on in-vitro methods that could be considered during information gap analysis for REACH registration purposes.

Year 2015

DB-ALM Newsletter (August 2015)
DB-ALM now provides non-guideline in vitro test methods in OECD compliant format.

DB-ALM Newsletter (April 2015)
Ten new reports have been published in the JRC QSAR Model Database to provide key information on computational methods in the areas of Human Health effects and Ecotoxic effects.

Year 2014

Release of the revised DB-ALM Version
In April 2014, the EURL ECVAM decided to release the first version of the revised DB-ALM, presented at the 9th World Congress on Alternatives and Animal Use in Life Sciences and formally launched in October. The revised DB-ALM Version covers the whole data sector of in vitro Methods with access to the Topic Summaries and all related information. It offers entirely redesigned search interfaces, based on controlled vocabularies/classification lists, and more flexible and precise data retrieval procedures without requiring deep knowledge of the DB-ALM information structure*.

*Note: The new data retrieval approach is already operational for the Methods data sector with access to the entire DB-ALM information content. The remaining data sectors will be subject to subsequent releases but they are still completely functional on the DB-ALM previous version.

DB-ALM Newsletter (October 2014)
In addition to the publication of the revised DB-ALM 2014 Version, the information content has been updated with method descriptions for in vitro methods compliant with regulatory requirements and/or undergoing validation by the EURL ECVAM in the areas of Carcinogenicity, Eye Irritation and Skin Sensitisation.

Year 2013

DB-ALM Newsletter (September 2013)
In addition to the publication of the updated version of the EURL ECVAM Search Guide, the DB-ALM information content has been updated with protocols of in vitro methods compliant with regulatory requirements and/or validated by the EURL ECVAM in the areas of Eye and Skin Irritation, Carcinogenicity and Acute Oral Toxicity and from the EU Integrated Project "ACuteTox" are available from the DB-ALM.

EU Bookshop: Second edition of the EURL ECVAM Search Guide is now available (August 2013)
Encouraged by the success of the first edition in 2012 the JRC has re-published an entirely updated version of the EURL ECVAM Search Guide. The Guide has specifically been developed to support untrained database users to find high quality information on relevant alternative strategies and methods to animal experiments in the large amount of available information resources. The Guide provides examples of search procedures, suggested search terms and user guidance. It includes descriptions of relevant resources and thesauri. A check list is moreover offered (the seven golden steps) to allow for searches in a structured and systematic way and to document them - a key part of preparing any research project in biomedical sciences and toxicology. Target users are scientists, national authorities involved in animal protection and ethical committees verifying that all possible alternatives have been considered before conducting animal experiments.
On Facebook: EU Law and publications.

EPAA Thematic Review project (January 2013)
The European Partnership for Alternative Approaches to Animal Testing (EPAA) supported and sponsored the Thematic Review project. The final report from the second survey on the use of in vivo reduction and refinement methods is now finalized and it is available on the DB-ALM website.

Year 2012

EPAA Dissemination Platform: Annual Report 2012 on EPAA Activities, The Market Place, page 10 (December 2012)
The European Partnership for Alternative Approaches to Animal Testing (EPAA) announces that the final report from the second survey on the use of in vivo reduction and refinement methods is close to finalisation and will be made available via DB-ALM website.

DB-ALM Protocol No.71 mentioned in OECD 460 Test Guideline 'Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants', (October 2012)

EU Bookshop (May 2012)
The ECVAM Search Guide has been published by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) of the European Commission Joint Research Centre. The Guide has specifically been developed to inform and support untrained database users to find high quality information on relevant alternative strategies and methods to animal experiments in an easy, yet systematic, efficient and effective way. It provides search procedures, selected search terms and user guidance in addition to an inventory of relevant resources. A printed version can be ordered or an e-version downloaded free of charge from the EU Bookshop, where in June the ECVAM Search Guide was in the top 10 list of the most downloaded publications.

Year 2011

Chemical Watch (May 2011)
Announcement on the Chemical Watch website about the progress of the European Partnership for Alternative Approaches to Animal Testing's (EPAA) Thematic Review Project, with a reference to the DB-ALM Newsletter sent out from the Institute for Health and Consumer Protection (IHCP) of the European Commission's Joint Research Centre (JRC).

The European Partnership for Alternative Approaches to Animal Testing (EPAA) Newsletter, Thematic Reviews, page 5 (March 2011)

Annual Report 2011 on Achievements of the European Partnership for Alternative Approaches to Animal Testing (EPAA), Platform on 3Rs In Regulation, page 5 (December 2011)

Year 2010

Annual Report 2010 on Achievements of the European Partnership for Alternative Approaches to Animal Testing (EPAA), Thematic Reviews, page 7 (December 2010)

ECHA Information toolkit
ECHA (European Chemicals Agency) suggests the use of ECVAM DB-ALM as a useful information source on in-vitro methods that could be considered during information gap analysis for REACH registration purposes.

The European Partnership for Alternative Approaches to Animal Testing (EPAA) is implementing the 'market place' concept for the 3Rs, EPAA Newsletter, page 1 & 3 (June 2010)
One of the EPAA objectives is to facilitate the dissemination of knowledge and information, bring it to those who need it, in the right format and with sufficient detail. The EPAA is building up a number of 'open stands' in the 'market place', to which belong Thematic Reviews.
The aim of these thematic reviews is to provide regulators and industry with concise, pre-digested and quality controlled information on existing alternative approaches for safety testing, and on their potential and limitations. The Thematic Review for Reproductive Toxicity Testing, one of the two topics that have been identified as legislative priorities was sponsored by EPAA and carried out with the direct involvement of the DB-ALM. The project was finalized in 2012. The results are available through the following link.

Year 2009

DB-ALM Protocol No.124 mentioned in OECD 437 Test Guideline 'Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants', (September 2009)

DB-ALM Protocol No.80 cited in OECD 438 Test Guideline 'Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants', (September 2009)
Data obtained using the above 2 protocols were successfully retrospectively validated by the US Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), later endorsed by ECVAM's Scientific Advisory Committee and finally adopted by the Organisation for Economic Co-operation and Development (OECD).
Based on the outcome of the studies, a new protocol version ( DB-ALM Nº 127) has been defined in compliance with the OECD Test Guideline No. 437 for its use as part of a tiered-testing strategy to classify substances as ocular corrosives or severe irritants without further testing in rabbits.

Disseminating 3Rs Information, Presentation at the EPAA Annual Conference (December 2009)

Year 2008

'Dissemination Strategies: How Do They Influence the Uptake of New Three Rs Methods Across Laboratories and Other Boundaries?', A Report of a Workshop held by the European Partnership for Alternative Approaches to Animal Testing (EPAA), Alternatives to Laboratory Animals (ATLA) 36(4), 453-458 (September 2008)

European Commission: Commissioner for Research Janez Potocnik's Dossier (2004-2009)

Red Iberoamericana de Toxicología y Seguridad Química (November 2008)

National Health and Medical Research Council, Australian Government, page L2 (June 2008)

Cosmetics &Toiletries (May 2008)

Pain and Distress Report, Volume 8, page 4 (January 2008)

European Commission: DG Environment, Protection of Laboratory Animals

Year 2007

Animal Welfare Information Centre Bulletin, Vol. 13/ Nr.1-2, page 14 (Summer 2007)

Good Medicine Magazine (USA), Vol. XVI / Nr. 2 (Spring 2007)

CORDIS focus Newsletter - Community Research & Development Information Service, page 9 (January 2007)

Alternatives to Animal Testing, Wikipedia

Westfälische Wilhelms-Universität Münster - Forschung -SAFIR (D)

NCA - Netherlands Centre Alternatives to Animal Use (NL) (March 2007)

Year 2006

Is animal testing necessary or useful? The debate goes on... (December 2006)

Dr. Hadwen Trust (UK) (December 2006)

ALTEX - Alternativen zu Tierexperimenten (November 2006)

Academy for Animal Welfare - Akademie für Tierschutz (D) (October 2006)

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